CARDIUM Therapeutics: Resources
Articles | Generx Studies | Websites | Annual Reports & Brochures
ARTICLES: Tissue Repair
Blume, P., Driver, V. R., Tallis, A. J., Kirsner, R. S., Kroeker, R., Payne, W. G., Wali, S., Marston, W., Dove, C., Engler, R. L., Chandler, L. A. and Sosnowski, B. K. (2011), Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers. Wound Repair and Regeneration, 19: no. doi: 10.1111/j.1524-475X.2011.00669.x
Mulder, G, Tallis A, Marshall T, Mozingo, D, Phillips, L, Pierce, G, Chandler L, Sosnowski B. Treatment of Nonhealing Diabetic Foot Ulcers with a Platelet-Derived Growth Factor Gene-Activated Matrix (GAM501): Results of a Phase 1/2 trial. Wound Repair and Regeneration. 17(6): 772-779 (2009).
Gu DL, Nguyen T, Phillips L., Chandler LA, Sosnowski B. Matrix-immobilized growth factor gene therapy enhances tissue repair. Wounds 16(1): 34-41 (2004).
Gu DL, Nguyen T, Gonzalez AM, Printz MA, Pierce GF, Sosnowski BA, Phillips ML, Chandler LA. Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use. Mol Ther. 9(5):699-711 (2004).
Doukas J, Chandler LA, Gonzalez AM, Gu D, Hoganson DK, Ma C, Nguyen T, Printz MA, Nesbit M, Herlyn M, Crombleholme TM, Aukerman SL, Sosnowski BA, Pierce GF. Matrix immobilization enhances the tissue repair activity of growth factor gene therapy vectors. Hum Gene Ther. 12(7):783-98 (2001).
Chandler LA, Gu DL, Ma C, Gonzalez AM, Doukas J, Nguyen T, Pierce GF, Phillips ML. Matrix-enabled gene transfer for cutaneous wound repair. Wound Repair Regen. 8(6):473-9 (2000).
ARTICLES: Heart Disease and GENE Therapy.
Meier et al, Circ. 2007; 116:975-983 - This long-term study published in the American Heart Association’s Journal, Circulation, evaluated coronary collateral blood flow in 845 patients with coronary artery disease during a 10-year follow-up period and demonstrated that long-term cardiac mortality was reduced by 75% in patients with a highly developed collateral vessel blood supply (p=0.0395)
In Heart Disease, the Focus Shifts to Women, New York Times, April 18, 2006.
WISE study of women and heart disease yields important findings on frequently undiagnosed coronary syndrome, National Institutes of Health report, January 31, 2006 (http://www.nhlbi.nih.gov/new/press/06-01-31.htm).
Advanced Gene Therapy Products. Compiled by Cardium Therapeutics, March 2010.
GENERX STUDIES
AGENT – “Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris ”, Grines et al. (2002) Circulation 105(11):1291-1297.
AGENT-2 – “A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina”, Grines et al. (2003) Journal of the American College of Cardiology 42(8):1339-1347.
AGENT Clinical Trials Review – “The AGENT clinical trials programme”, Grines (2004) European Heart Journal Supplement 6(Suppl E):E18-E23.
AGENT-3 and AGENT-4 – “Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials”, Henry et al. (2007) Journal of the American College of Cardiology 50(11):1038-1046.
Ischemia-reperfusion increases transfection efficiency of intracoronary adenovirus type 5 in pig heart in situ, Shi et al. (2012) Human Gene Therapy Methods 23(3):204-12
(For reprints please contact Cardium)
WEBSITES
ACLS Certification Institute Online Medical Library: Anatomy of the Heart
http://www.aclscertification.com/pages/ acls-online-resources-anatomy-of-the-heart.html
ACLS Certification Institute Online Medical Library: How Angioplasty Works http://www.aclscertification.com/pages/ howangioplastyworks.html
ACLS Certification Institute Online Medical Library: A Guide to Angioplasty
http://www.aclsrecertificationonline.com/ acls-online-library-a-guide-to-angioplasty.html
ACLS Certification Institute Online Medical Library
http://www.aclscertification.com/pages/ resources.html
American Diabetes Association, www.diabetes.org
American Heart Association, www.heart.org
The American Society of Gene and Cell Therapy (ASGTC), www.asgt.org
BetterInvesting, www.betterinvesting.org/openhouse
Gene Therapy Net, genetherapynet.com
Go
Red for Women, www.goredforwomen.org
National Women's Health Resource Center, www.Healthywomen.org
National Coalition of Women with Heart Disease, www.womenheart.org
National Heart, Lung and Blood Institute, www.nhlbi.nih.gov
World Health Organization, www.who.int/cardiovascular_diseases/en/